The major focus of the Lindsley laboratory is drug discovery and medicinal chemistry. Students in my lab will collaborate with other members of the Pharmacology, Drug Metabolism and Clinical Pharmacology departments to pursue small molecule hits from high throughput screens, perform lead optimization studies to develop structure-activity-relationships (SAR) and ultimately deliver small molecules with acceptable properties to validate novel targets/mechanisms in in vivo animal models of target diseases.

After receiving her undergraduate Chemistry degree (Cornell University) and Ph.D. degree (University of Pennsylvania, Chemistry), Donna M. Huryn began her career as a medicinal chemist in the pharmaceutical industry (Hoffmann-La Roche & Wyeth Research), and contributed to drug discovery efforts for HIV, cancer, asthma, and CNS disorders with increasing levels of responsibility.

Peng Zhan is now working as a full professor in Shandong University. His research interests involve the discovery of novel antiviral, anticancer, and neurodegenerative diseases-related agents based on rational drug design and combinatorial chemistry approaches.

Philipp TSVETKOV holds PhDs in Molecular Biology (Aix-Marseille Université, France) and in Physics & Mathematics (Moscow, Russia). He specializes in protein–metal and protein–drug interactions studied with biophysical methods. At the Institute of Neurophysiopathology (Aix-Marseille Université), his research focuses on the molecular mechanisms of neurodegeneration and zinc signaling. He also run the Biophysical Instrumental Platform, where he directs the development of new approaches in cancer diagnostics and anticancer drug discovery. He is the author of 70+ publications and an inventor on several patents.